Bridging Sequence Structure Alignment in RNA Foundation Models (AAAI 2025) Model Description OmniGenome is an advanced RNA foundation model that introduces sequence structure alignment to genomic modeling. The model bridges the gap between RNA sequences and their secondary structures, enabling bidirectional mappings that improve the flow of genomic information between RNA sequences and structures. With OmniGenome, researchers can achieve improved performance in RNA related tasks, such as RNA design, secondary structure prediction, and various downstream genomic tasks. It also demon... Model type : Transformer based (52M and 186M parameter versions) Languages : RNA sequences and structures Pretraining : The model is pretrained on RNA sequences from over 1,000 plant species from the OneKP database. Secondary structures were predicted using ViennaRNA. Key Features : Seq2Str (Sequence to Structure) and Str2Seq (Structure to Sequence) mapping RNA design and secondary structure prediction Generalizability to DNA genomic tasks Intended Use This model is ideal for: RNA secondary structure prediction RNA design via structure to sequence mapping Genomic sequence understanding tasks, such as…
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